Endocrinology MCQs

316 MCQs with clinical pearls · MBBS Biochemistry · Prof Jariya

Practise these MCQs free →

Topics covered (34)

Hormone Signal Transduction — 31 MCQs
Infertility — 30 MCQs
Contraception — 23 MCQs
Thyroid Hormones — 22 MCQs
Cortisol — 15 MCQs
Cushing Syndrome — 14 MCQs
Growth Hormone — 14 MCQs
Insulin Signalling — 12 MCQs
Vitamin D and Calcium — 12 MCQs
Hormone Effects on Metabolism — 10 MCQs
Sex Steroids — 10 MCQs
Male Infertility — 10 MCQs
Congenital Adrenal Hyperplasia — 9 MCQs
Signal Transduction and Feedback — 9 MCQs
Glucose Transporters — 7 MCQs
Glucagon Signalling — 7 MCQs
Aldosterone — 7 MCQs
Prolactin — 7 MCQs
Hormone Transport and Clearance — 7 MCQs
Adrenal Cortex and POMC — 7 MCQs
Addison Disease — 6 MCQs
Diabetes Mellitus — 6 MCQs
Insulin Secretion — 5 MCQs
Hormone Classification — 5 MCQs
Adrenal Medulla and Catecholamines — 5 MCQs
Pituitary — 5 MCQs
ADH — 4 MCQs
Steroid Hormone Biochemistry — 3 MCQs
Catecholamines — 3 MCQs
Calcium Metabolism — 3 MCQs
Miscellaneous — 3 MCQs
Cholesterol Metabolism — 2 MCQs
Insulin Resistance — 2 MCQs
Phaeochromocytoma — 1 MCQs

Sample MCQs with clinical pearls

Antidiuretic hormone (ADH) acts on vascular smooth muscle through which of the following second messenger pathway?

A) cAMP

B) cGMP

C) IP3 and DAG ✔

D) JAK-STAT

E) STATS

ADH acts through TWO receptor types. The V1 receptor on vascular smooth muscle couples to Gq, activating PHOSPHOLIPASE C to generate IP3 and DAG - IP3 releases calcium and causes VASOCONSTRICTION, which is why ADH is also called VASOPRESSIN. The V2 receptor on the collecting duct uses cAMP instead. One hormone, two receptors, two second messengers, two actions. MEMORY: 'V1 for vessels through IP3; V2 for water through cAMP.'

Antidiuretic hormone (ADH) acts on the renal collecting duct epithelium to promote water reabsorption through which of the following second messenger?

A) cAMP ✔

B) cGMP

C) IP3 and DAG

D) JAK-STAT

E) MAP kinase

The V2 receptor of the collecting duct couples to Gs, raising CAMP and activating protein kinase A, which inserts AQUAPORIN-2 channels into the apical membrane so water is reabsorbed. Loss of this pathway causes NEPHROGENIC diabetes insipidus - from V2 receptor or aquaporin-2 mutations, or from lithium. Desmopressin is a selective V2 agonist, giving antidiuresis without vasoconstriction. MEMORY: 'cAMP puts the water channels in place.'

Which of the following hormones acts via the cAMP signalling mechanism?

A) Estrogen

B) Glucagon ✔

C) Insulin

D) Oxytocin

E) Progesterone

GLUCAGON acts through a Gs-coupled receptor, raising CAMP and activating protein kinase A, which phosphorylates and ACTIVATES glycogen phosphorylase while INACTIVATING glycogen synthase - so glycogen is broken down and glucose released. Other cAMP hormones include adrenaline at beta receptors, ACTH, TSH, LH, FSH, PTH and calcitonin. Insulin, by contrast, uses a receptor tyrosine kinase. MEMORY: 'Glucagon raises cAMP and the liver releases glucose.'

These are three of 316 MCQs in this section. Every question carries a clinical pearl explaining the reasoning.

Open MCQ Arena →